("Irreversibility" refers to the effect on a single copy of the enzyme the effect on the overall human digestive system is reversible, as the enzymes are naturally destroyed and replaced with new copies.) Targeting the terminal step in acid production, as well as the irreversible nature of the inhibition, results in a class of drugs that are significantly more effective than H 2 antagonists and reduce gastric acid secretion by up to 99%. The proton pump is the terminal stage in gastric acid secretion, being directly responsible for secreting H+ ions into the gastric lumen, making it an ideal target for inhibiting acid secretion. Proton pump inhibitors act by irreversibly blocking the hydrogen/potassium adenosine triphosphatase enzyme system (the H+/K+ ATPase, or more commonly gastric proton pump) of the gastric parietal cells.
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